Statistics

Modeling single cell RNAseq data with multinomial distribution

I was reading Feature Selection and Dimension Reduction for Single Cell RNA-Seq based on a Multinomial Model. In the paper, the authors model the scRNAseq counts using a multinomial distribution. I was using negative binomial distribution for modeling in my last post, so I asked the question on twitter: for modeling RNAseq counts, what’s the difference/advantages using negative binomial and multinomial distribution? — Ming Tang (@tangming2005) November 26, 2019 some quotes from the answers I get from Matthew